![]() Well, we need to go back to the role of excess nitric oxide in triggering ACE inhibitor cough. The iron group saw a 77% reduction in cough symptoms the antioxidant group had 38% reduction and there was no change in the placebo group. This is supported by a 2011, four week study, where 28 participants received either iron supplementation (200mg ferrous sulphate/day) antioxidant supplementation of (200mg of Vitamin E and 150mg of Vitamin C) or a placebo. Could iron supplementation and antioxidants be the answer?Ī 2001 randomised, doubled blinded placebo controlled trial of 19 patients with ACE inhibitors cough showed that iron supplementation of (256mg ferrous sulphate) over four weeks significantly reduced the cough scores. These kinins are normally degraded by angiotensin converting enzyme but when they accumulate they cause excess production of nitric oxide, a molecule that is inflammatory and irritating to the lining of the airways. Well, the mechanism of ACE inhibitor cough is not completely understood but most researchers believe it involves excess inflammatory proteins (bradykinins and tachykinins) accumulating in the upper airways. This increases the excretion of water and sodium, reducing the volume of fluid in your body and thereby decreasing blood pressure. Secondly, they inhibit the release of the hormone aldosterone. A larger diameter blood vessel means lower pressure. Firstly, they block the angiotensin-converting enzyme preventing blood vessels constricting. How do ACE inhibitors work to lower blood pressure?ĪCE inhibitors have a dual action on blood pressure. (Yes, the common theme is they all end in “pril”!) Unfortunately, the irritation of the cough can be enough for some people to discontinue their medication and this could have very serious consequences. You may know them under the brand names captopril, perindopril, ramipril and enalapril. The good news is that there are some nutritional and diet options that can keep you on your medication and reduce or eliminate that irritating cough.ĪCE inhibitors are a commonly prescribed and effective class of drugs used to manage high blood pressure, congestive heart failure and diabetic nephropathy. ![]() ![]() The ACE inhibitor cough side effect occurs in up to 35% of people taking this medication. ![]() Have you developed a persistent dry cough, with a tickling sensation in your throat since you started taking angiotensin converting enzyme inhibitors (ACE inhibitors)? Well, you are not alone. ![]()
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